It has been suggested that combinatorial therapies may increase the efficacy in patients with dysregulation of both MDM2 and CDK4. Synergy between CDK4/6 and MDM2 inhibitors has been observed in preclinical studies in liposarcoma48, melanoma,49 and breast cancer50, although contradictory results have been reported regarding the synergistic effects of a combined MDM2 and CDK4 targeting strategy in sarcoma48,51. The gene discussed is CDK4; the disease is melanoma.