CDK4 and neuroblastoma: Analysis of two datasets consisting of 88 and 498 NB tumors, publicly available in the R2 database, indicates that high expression of these three genes is associated with low overall survival, with the strongest association between adverse outcome and high expression levels for CDK4 (p = 9.1 × 10–8 and p = 2 × 10–20, respectively) (Supplementary Table 2).