PHOX2B and neuroblastoma: The sequenced tumors lacked pathogenic variants in ALK, PHOX2B, TP53, or genes of the RAS-MAPK signaling pathway, which have previously been connected to NB, as well as variants in WT1, TRIM28, FBXW7, NYNRIN, or KDM3B, genes previously linked to Wilms’ tumor45.