The sequenced tumors lacked pathogenic variants in ALK, PHOX2B, TP53, or genes of the RAS-MAPK signaling pathway, which have previously been connected to NB, as well as variants in WT1, TRIM28, FBXW7, NYNRIN, or KDM3B, genes previously linked to Wilms’ tumor45. Here, KDM3B is linked to neuroblastoma.