The sequenced tumors lacked pathogenic variants in ALK, PHOX2B, TP53, or genes of the RAS-MAPK signaling pathway, which have previously been connected to NB, as well as variants in WT1, TRIM28, FBXW7, NYNRIN, or KDM3B, genes previously linked to Wilms’ tumor45. This evidence concerns the gene FBXW7 and neuroblastoma.