In other tumor types displaying the co-amplification of 12q13.3–14.1 and 12q15, CDK4 and MDM2 are often reported as possible targets for the respective regions25,28–30, and in our cohort of 12q-amplified cases, amplification of CDK4 was seen in 18 out of 19 samples, while amplification of MDM2 was seen in 16 out of 19 samples (Fig. 1 and Supplementary Fig. 1). Here, CDK4 is linked to neoplasm.