Interestingly, our study demonstrates a treatment strategy using the selective SET7/9 inhibitor Set7_1a, which could interact with Hcy via ligand exchange, enhance HIF-1α stabilization of HUVECs in the presence of Hcy, and promote the expression of angiogenic proteins, such as VEGF, GLUT1 and EPO, in hypoxia and hyperglycemia. This evidence concerns the gene EPO and Hyperglycemia.