In the co-IP results, Set7_1a did not decrease the amount of HIF-1α coprecipitating with SET7/9 in hyperglycemia-induced HUVECs in hypoxia, indicating that it did not affect the interaction of SET7/9 and HIF-1α in the treated cells (Fig. 3b). The gene discussed is HIF1A; the disease is Hyperglycemia.