HIF1A and Hyperglycemia: Interestingly, our study demonstrates a treatment strategy using the selective SET7/9 inhibitor Set7_1a, which could interact with Hcy via ligand exchange, enhance HIF-1α stabilization of HUVECs in the presence of Hcy, and promote the expression of angiogenic proteins, such as VEGF, GLUT1 and EPO, in hypoxia and hyperglycemia.