The mean value of BMI, the frequencies of low education, use of anti-hypertensive agents, hypertension, use of lipid-modifying agents, obesity, diabetes mellitus, use of glucose-lowering agents, and electrocardiogram abnormalities, and the geometric means of serum ALT increased significantly with higher levels of serum SAM, while the mean value of serum total cholesterol decreased significantly with higher levels of serum SAM (Table 1 and Supplementary Table S1). This evidence concerns the gene GPT and obesity due to melanocortin 4 receptor deficiency.