SIRT6 and Hypoglycemia: We did not observe any effects in body and muscle weights, or in muscle morphology in Sirt6mKO compared to WT mice, which is in contrast to germline Sirt6 knockout mice (Sirt6−/−) that are smaller in size, show severe metabolic dysfunctions including hypoglycemia and loss of subcutaneous fat and display signs of skeletal muscle degeneration44.