Importantly, deletion of Sirt6 in Utrn−/−/mdx mutant mice did not reduce Evan’s blue uptake demonstrating that upregulation of Utrn due to the absence of SIRT6-mediated repression is critical for improvement of the muscular dystrophy phenotype in mdx mice (Fig. 7b). This evidence concerns the gene SIRT6 and muscular dystrophy.