SIRT6 and Glucose intolerance: In contrast to germline Sirt6 knockout mice (Sirt6−/−), which show severe metabolic dysfunctions, we did not find evidence for glucose intolerance in Sirt6mKO mice or transcriptional activation of glycolytic genes that are repressed by SIRT6 in other cell types29 (Supplementary Fig. 2i–n).