Genes related to DNA methylation, demethylation, and chromatin modifications, such as DNMT1, DNMT3A, DNMT3B, TET1, TET2, IDH1, IDH2, ASXL1, and EZH2, did not show significant differences in 5hmC levels between AML and control samples (Supplementary Fig. 4). Here, IDH2 is linked to acute myeloid leukemia.