Taken together with the data that LATS1/2 directly regulate two EMT-TFs, including SLUG during MET or subsequent epithelial stage (Figs. 5, 6) and SNAIL during EMT18, it is possible that when the Hippo pathway-mediated growth inhibitory system is disrupted by genetic mutation or oncogenic stress, the core components of this pathway become independent of one another and might play distinct and independent roles in EMT and cancer progression via interactions with new partners30. The gene discussed is SNAI1; the disease is cancer.