Importantly, the CD4 and CD8 T cell response elicited by BCGΔBCG1419c were also more likely to contain IL10-producing cells (Fig. 10C), which may underlie the less inflammatory nature of BCGΔBCG1419c during chronic TB stages since IL10 suppresses via antigen presentation, via retention of mycobacterial peptide:MHC-II complexes in endosomal fractions (away from the cell surface)56 and/or negative regulation of costimulatory molecule expression57,58. The gene discussed is CD4; the disease is tuberculosis.