Compared to DCIS, MIBC is seen in association with high nuclear grades, necrosis, human epidermal growth factor receptor 2 (HER-2) positivity and a high Ki-67 positivity index, whereas the rates of estrogen receptor (ER) and progesterone receptor (PR) positivity are lower in patients with microinvasive carcinoma arising the background of extensive DCIS12. Here, ERBB2 is linked to ductal breast carcinoma in situ.