It is recognized recently that multiple E3 ubiquitin ligases play critical roles in the transformation, epithelial–mesenchymal transition (EMT), and metastasis of cancers by inducing ubiquitination of its target proteins [27, 28], whereas whether E3 ligase MG53 plays a role in the progression of HCC remains to be clarified. The gene discussed is TRIM72; the disease is hepatocellular carcinoma.