RAC1 and hepatocellular carcinoma: The data showed that MG53 could conjugate the poly-ubiquitination chain to RAC1 (Fig. 3C) and the endogenous ubiquitination assay showed that knockdown of MG53 could abrogate the ubiquitination modification of RAC1 in HCC cells (Fig. 3D), which indicated that MG53 could catalyze RAC1 ubiquitination modification in HCC cells.