The inability of Tau to efficiently bind and colocalize with non-polyglutamylated Tuba4a prompted us to analyze the Tau phosphorylation status, since Tau hyper-phosphorylation and microtubule-detachment are hallmarks in Alzheimer ́s disease (AD) and other tauopathies2,47,48. Here, TUBA4A is linked to early-onset autosomal dominant Alzheimer disease.