TUBA4A and early-onset autosomal dominant Alzheimer disease: In a further approach, we crossbred wild-type (+/+) or Tuba4a mutant mice (p/p) with a tauopathy mouse model (hTau), known for its Alzheimer ́s disease-like pathology, as characterized by the pathologic oligomerization of hyper-phosphorylated Tau in cell bodies and dendrites.