Similar to the normalization of hyper-phosphorylated Tau (Fig. 7F–H and Supplementary Fig. 9A–C), hTau/Tuba4aΔpolyGlu animals, lacking Tuba4a polyglutamylation revealed normalization of Tau oligomeric assemblies, as compared to hTau tauopathy mice (Fig. 8A–C). Here, TUBA4A is linked to tauopathy.