Strikingly, following crossbreeding of Tuba4aΔpolyGlu (p/p) mice with hTau tauopathy mice, the phosphorylation of Tau (AT8 and AT270) was significantly reduced in the resulting hTau/Tuba4a-ΔpolyGlu condition, (Fig. 7A, black condition and Fig. 7B, C), as compared to the tauopathy hTau condition only (dark gray condition). The gene discussed is TUBA4A; the disease is tauopathy.