The extracts of Tripterygium wilfordii Hook F, demethylzeylasteral (T-96), and methylprednisolone (MP) have been shown to improve MRL/lpr susceptibility to SLE by inhibiting the NF-κB signalling pathway in rats with lupus nephritis [44, 45]. Here, NFKB1 is linked to systemic lupus erythematosus.