TAT and neoplasm: Given that macropinocytosis is a key CIE pathway for the uptake of Tat-based non-viral nanoparticles [7, 14, 16, 21, 29], and Tat-compacted pDNA complexes mainly use macropinocytosis for uptake in malignancies [6, 7], investigating whether macropinocytic uptake of nanoparticles was varied during the cell-cycle of OC cells, exploiting whether GRP75-interuption affected cell-cycle-dependent macropinocytosis, and capitalizing such feature for highly efficient suicide gene therapy should increase our understanding for development of tumor-targeted suicide gene therapy.