MAPT and Alzheimer disease: In both the COMTKO/P301L and P301L mice, KEGG analyses revealed that the top ten over-represented pathways 24 h after anesthesia included those involved in multiple neurodegenerative disease pathogenesis (Huntington’s disease, Parkinson’s disease, prion disease, and Alzheimer’s disease) as well as the thermogenesis pathway that may be directly related to the effects of anesthesia on tau hyperphosphorylation (Fig. 2C, D).