α7nAChR-selective agonist PNU28298759 and partial agonist encenicline60 (the effects of which are significantly attenuated by MLA) inhibit the development of DSS-induced colitis, reflected by less histological damage,59,60 less macrophage infiltration,59,60 and lower tissue levels of cytokines.59 This evidence concerns the gene CHRNA7 and colitis.