α7nAChR KO mice demonstrate more severe responses to dextran sulfate sodium (DSS)-induced colitis, with more severe symptoms, higher disease activity scores, higher tissue and serum levels of cytokines (IL-1β, IL-6, IL-18, and TNF-α), and higher mortality rates,38,57 though not all studies confirm this finding.58 Here, CHRNA7 is linked to colitis.