PPARG and Leber hereditary optic neuropathy: Furthermore, the activation of the PPAR-γ/PGC1-α pathway through the induction of uncoupling protein 2 (UCP2) may also impinge on mitochondrial decoupling, reducing Ψm and ROS production and ultimately limiting oxidative damage and propensity to undergo apoptosis of LHON cells (Andrews et al., 2005).