ZNF257 and lung cancer: To explore the mechanistic relationship between KZNFs and TE RNA expression, we examined mutant KRAS A549 lung cancer cells that overexpress ZNF257 or ZNF682 (Ito et al., 2020), both of which we found to be significantly downregulated by mutant KRAS signaling in AALE cells and putative regulators of dysregulated TE families (Figures 1A and S3).