CD274 and colorectal carcinoma: Nevertheless, our findings highlight the function of SA14 as a regulator of chemoresistance and immune surveillance and the potential of SA14 expression as valuable biomarkers for patients with CRC, such as loss of SA14 as an unfavourable prognostic factor and a predictive biomarker for responsiveness to chemotherapy and anti‐PD‐L1‐based immunotherapy combination.