Middle cerebral artery occlusion (MCAO) wasperformed to establish a cerebral ischemia/reperfusion (I/R) model.Specific-pathogen-free male Sprague-Dawley rats were randomly divided into Sham,I/R, DEX, DEX+IL-6, and AG490 (a selective inhibitor of JAK2) groups. This evidence concerns the gene JAK2 and brain ischemia.