In addition to the exploration of the sequence of these genes in constitutional and tumour DNA, we explored the expression pattern of both genes in tumour and cell lines of various tissue origins, and searched for relationships between AGR2 and AGR3 gene expression and several oncogenic determinants in various cancer types, tumours or cell lines, especially copy number variations (CNVs) and point mutations (single-nucleotide variations, SNV). This evidence concerns the gene AGR3 and cancer.