In this respect, we have selected in the TCGA the five tumour types (COADREAD, BRCA, LUAD, LUSC and OVCA) and the set of genes that are the most commonly mutated in these malignancies (KRAS, APC, TP53, SMAD4, BRAF and PIK3CA for COADREAD; TP53, PIK3CA, BRCA1/2 and PTEN for BRCA; KRAS and TP53 for LUAD and LUSC; TP53, BRCA1/2 and RB1 for OVCA). This evidence concerns the gene SMAD4 and neoplasm.