In the BRCA samples of TCGA, we also noticed a significant relationship between AGR2 expression and FOXA1 gene copy number, as well as several cancer gene copy numbers localized at 14q such as NFKBIA, SAV1, CHD8 or AJUBA, which are not known as driver oncogenes or TSG in breast cancer (figure 7b; electronic supplementary material, table S4A). The gene discussed is CHD8; the disease is cancer.