CD4 and neoplasm: Genes encoding for T cell infiltration (Cd3e, Cd4, Cd8a, and Foxp3), T cell activation (Prf1, Cd69, Gzma, Pdcd1, Ctla4, and Lag3), IFN responses (Irf7, Irf9, and Cd274), and antigen presentation (H2-Ab1, H2-K1, H2-D1, Ciita, and B2m) were up-regulated after treatment, while immunosuppressive cytokines (Cxcl1 and Csf2) and markers of tumor-promoting myeloid populations (Arg1) were down-regulated (Fig. 8D and fig.