Furthermore, we demonstrate that atorvastatin markedly attenuates a host of post-RFA tumorigenesis-inducing phenomenon including release of HGF and key dependent growth factors such as FGF-19 and VEGFR-1, as well as tumor markers such as Ki-67 and CD34 implicating fibroblast proliferation in a cascade that leads to proliferation and angiogenesis. Here, HGF is linked to neoplasm.