BRCA1 and cancer: When we restricted the survival analysis to the subset of patients in the TCGA OvCa cohort that received optimal debulking, we confirmed that patients with BRCAmut OvCas had better overall survival (HR = 0.54, P = 0.006, Fig. 5B and table S3), whereas BRCA1 methylation status did not provide any benefit in terms of overall survival, even in this subgroup of patients with optimally debulked cancers.