IFNG and COVID-19: While there are fewer studies focused on the clinical correlates of T cell responses to SARS-CoV-2, some reports during acute infections found evidence for greater T cell response magnitude in severe COVID-19 (11, 12), whereas others found IFN-γ-producing SARS-CoV-2-specific Th1 and CD8+ T cell responses (13, 14), as well as cTfh cells (13), were inversely correlated with disease severity during acute COVID-19.