Moreover, at least 13.6% of unvaccinated patients with critical COVID-19 had auto-Abs neutralizing lower, more physiological concentrations (100 pg/mL in plasma diluted 1/10) of IFN-α2 and/or IFN-ω, while auto-Abs neutralizing IFN-β were found in another 1% of patients (22). Here, IFNA2 is linked to COVID-19.