IFNA2 and COVID-19: In more than 34,000 uninfected individuals aged 18 to 100 years, the prevalence of auto-Abs neutralizing 10 ng/mL (or 100 pg/mL) of IFN-α2 or IFN-ω increased significantly with age, with 0.17% (1.1%) of individuals positive for these auto-Abs under 70 years old, and more than 1.4% (4.4%) positive over 70 years old, consistent with the higher risk of life-threatening COVID-19 in the elderly population (22).