To add to the controversy, knocking out ASNS did not sensitize melanoma cells to ASNase treatment in vivo (12), and ASNase-induced ASNS expression failed to prevent cell cycle arrest in ASNase-sensitive leukemic cells carrying Translocation-Ets-leukemia or ETV6/Acute Myeloid Leukemia 1 (TEL/AML1) fusion gene (13, 14). This evidence concerns the gene RUNX1 and leukemia.