We know that STAT1/STAT3 phosphorylation is a key event in PD-L1 expression and increases the amount of inflammatory-promoting T cell infiltration in tumor tissue.12 Base on these results, we speculated that anlotinib was conducive to developing an immune-supportive microenvironment and could potentially increasing the expression of PD-L1. The gene discussed is CD274; the disease is neoplasm.