ALB and diabetes mellitus: Although the American College of Rheumatology (ACR) [8] has not defined the causal role of urates in “non-gout” diseases, recent clinical studies have shown that urate-lowering treatment can decrease urinary albumin excretion rate (UAER) and Scr, increase eGFR, and reduce the severity of proteinuria in patients with diabetes; thus, urate-lowering treatment may become an adjuvant cost-effective therapy for diabetes mellitus [1,2,5].