Although many TPGs predispose to a single or limited types of tumors (e.g., ATM, 11p15/CDKN1C, CDH1, PAX5, PTPN11, SMARCB1), based on the observed tumor spectrum, KMT2D would belong to a group of TPGs predisposing to a broader spectrum of tumours like seen for TP53, PTEN, STK11 and DICER1. This evidence concerns the gene PTEN and neoplasm.