As suggested by the current study, analyzing immune patterns might gain additional information beyond single marker analyses, exemplified here by 1) the indicated mediating mechanism of neuroinflammation of NLRP3 and NLRC4 inflammasome linked CAMs assistance of leucocyte transmigration, 2) displaying links between BBB integrity markers in BD, and 3) suggesting interplay of different anti-inflammatory pathways in illness course severity. Here, NLRP3 is linked to Behcet disease.