In the present study, we used the abnormal gene expression profile and mutant gene information of GBM patients to identify nine potential mRNA vaccine antigen candidates, namely ADAMTSL4, COL6A1, CTSL, CYTH4, EGFLAM, LILRB2, MPZL2, SAA2, and LSP1. This evidence concerns the gene COL6A1 and glioblastoma.