TP53 and neoplasm: Growing evidence have demonstrated that JMJD3 induces p16 and p21 activation via up-regulation of P14, Rb and p53, contributing to cell cycle arrest and inhibition of tumor proliferation; this means JMJD3 may serve as a tumor suppressor gene, and the mechanism of JMJD3 in the tumor cell arrest in our study was shown in Fig. 4 (Ene et al., 2012; Zhao et al., 2015; Zhao et al., 2013).