JMJD3 is involved in carcinogenesis, such as proliferation, differentiation, apoptosis, and aging through many signaling pathways, and the expression pattern of JMJD3 in different cancers is still controversial (Lagunas-Rangel, 2021; Park et al., 2016; Pereira et al., 2011; Tokunaga et al., 2016; Xiang et al., 2007; Zhang et al., 2020). Here, KDM6B is linked to cancer.