Regarding tumor suppression, JMJD3 could inhibit tumor cell proliferation by regulating vitamin D or enhancing apoptosis through the nuclear translocation of FOXO1 in many cancer types, like colorectal cancer, non-small cell lung cancer or pancreatic cancer (Ma et al., 2015; Pereira et al., 2011; Tokunaga et al., 2016; Yamamoto et al., 2014). The gene discussed is KDM6B; the disease is cancer.