The present results demonstrated that the lncRNA PINK1-AS, as a sponge for miR-203, aggravates oxidative stress injury that is due to cerebral ischemia followed by a short reperfusion, and its action mechanism involves highly expressed PINK1-AS endogenously competing with miR-203, thus, resulting in upregulation of ATF2 and NCF2 (both targets of miR-203), which leads to upregulation of NOX2 and generation of excessive ROS (Figure 7). Here, CYBB is linked to brain ischemia.