NFKB1 and lobular neoplasia: The NF-κB family is known to play a necessary role in the progression of LN as key nuclear transcription factors that activate the secretion of inflammatory factors, chemokines [32], etc. The process of NF-κB activation is primarily the degradation of IκB phosphorylation in the cytoplasm and NF-κB entry into the nucleus to activate downstream inflammation-related target-gene expression [33].