We further confirmed through the results of GEO data analysis that FXR (NR1H4) expression obviously decreased in the kidneys of patients with LN (P < 0.01; Figures 4(b)–4(d)) and the degree of inhibition was strongly associated with disease progression and poor prognosis (P < 0.01; Figure 4(e)). The gene discussed is NR1H4; the disease is lobular neoplasia.