Functional enrichment analysis was conducted to confirm whether these differentially expressed NRGs had associations with necroptosis in LIHC, which showed these NRGs were correlated with programmed necrotic cell death, positive regulation of interleukin-8 production, TNF signaling pathway, NF-kappa B signaling pathway, Toll-like receptor signaling pathway, and Herpes simplex infection. The gene discussed is CXCL8; the disease is herpes simplex infectious disease.