MAPK1 and diabetic kidney disease: The analyses demonstrated that both positive and negative regulation of biological processes (BP) were involved in the treatment of DKD, including positive regulation of protein kinase B signaling, angiogenesis, ERK1, and ERK2 cascade, glycolytic process and vascular smooth muscle cell proliferation, negative regulation of blood pressure, and other processes, such as xenobiotic metabolic process, glucose homeostasis, response to drug, and angiogenesis.