MMP8 and periodontitis: The results indicated that the AUCs of IL-6, IL-1β, IL-8, BGP, and MMP-8 levels in predicting drug treatment failure in patients with severe periodontitis were all greater than 0.7, indicating that the above indexes had a certain predictive value for drug treatment failure severe periodontitis, and the best predictive value could be obtained when the index reaches the optimal truncation value.