The results indicated that the AUCs of IL-6, IL-1β, IL-8, BGP, and MMP-8 levels in predicting drug treatment failure in patients with severe periodontitis were all greater than 0.7, indicating that the above indexes had a certain predictive value for drug treatment failure severe periodontitis, and the best predictive value could be obtained when the index reaches the optimal truncation value. Here, IL6 is linked to periodontitis.