KEGG enrichment analysis showed that 11 of the top 15 signaling pathways with significant enrichment of hub genes and potential genes were the same, including malaria, African trypanosomiasis, inflammatory bowel disease (IBD), allograft rejection, graft-versus-host disease, IL-17 signaling pathway, asthma, leishmaniasis, pertussis, chagas disease (American trypanosomiasis), and rheumatoid arthritis. The gene discussed is IL17A; the disease is rheumatoid arthritis.