IDE and Senile plaques: Yang et al. [35] found that giving two courses of EA treatment and three courses of EA treatment led to different outcomes, after two courses of EA, no significant effects were observed in the number of senile plaques (SPs) or the expression of β-site APP-cleaving enzyme 1 (BACE1) and insulin-degrading enzyme (IDE) in the cortex, but three courses of EA has a significant effect on these parameters.