Except for pathways in cancer, PPAR signaling, amyotrophic lateral sclerosis, fluid shear stress and atherosclerosis, viral myocarditis, transcriptional misregulation in cancer, prion diseases, endocytosis, endocrine resistance, dopaminergic synapse, cytokine-cytokine receptor interaction, complement and coagulation cascades, apoptosis-multiple species, antigen processing and presentation, allograft rejection, and other signal pathways only have one gene. This evidence concerns the gene PPARA and amyotrophic lateral sclerosis.