SPP1 and glioblastoma: In general, GBM cells with high expression of PTX3 showed a strong interaction with microenvironment cells via the ADIPONECTIN, FASLG, ANGPT, GH, GRN, IL6, IFN‐I, IFN‐II, PERIOSTIN, PROS, TWEAK, SEMA3, and SPP1 signaling pathways (Figures S13–S15).