In general, GBM cells with high expression of PTX3 showed a strong interaction with microenvironment cells via the ADIPONECTIN, FASLG, ANGPT, GH, GRN, IL6, IFN‐I, IFN‐II, PERIOSTIN, PROS, TWEAK, SEMA3, and SPP1 signaling pathways (Figures S13–S15). This evidence concerns the gene TNFSF12 and glioblastoma.