Univariate and Multivariate analysis were shown in Table S3, expression of GPX4 (p = 0.014, 95% CI: 0.58–0.94; HR: 0.74), NOX1 (p = 0.026, 95% CI: 1.03–1.67; HR:1.31), and FACL4 (p = 0.015, 95% CI: 1.21–1.66; HR:1.34) were independent factors for OS in CRC. The gene discussed is GPX4; the disease is colorectal carcinoma.