SNCA and neurodegenerative disease: Widespread oligodendroglial cytoplasmic inclusions (GCIs or Papp-Lantos bodies) associated with striatonigral or olivopontocerebellar neurodegeneration are the histological hallmark of multiple system atrophy.2 The main constituent of the GCIs is misfolded α-synuclein,3 which classifies multiple system atrophy as oligodendroglial α-synucleinopathy, while neuronal α-synuclein aggregates (Lewy bodies) characterize Parkinson’s disease4 and dementia with Lewy bodies.5