ALDH1A1 and glioblastoma: Aldehyde dehydrogenases detoxify anticancer drugs and function as antioxidants by reversing lipid peroxidation and repairing etheno-DNA adducts, thus maintaining REDOX homeostasis that confers chemotherapy and radiation failure.3 ALDH1A1 also catalyzes the conversion of retinaldehyde to retinoic acid resulting in the stemness phenotype that causes tumor re-population.4 These functions of ALDH1A1 make it a target of interest in two ongoing clinical trials of disulfiram in newly diagnosed and relapsed GBM.