The genes of yellow module might be involved in the formation of adhesive plaque and the interaction of extracellular matrix (ECM) receptors; the genes of purple module gene might be related DNA replication, cell cycle regulation, homologous recombination and the p53 signalling pathway related to the occurrence and development of breast cancer; while the genes of brown module might be involved in pyrimidine nucleotide metabolism and other processes. The gene discussed is TP53; the disease is breast cancer.