BAX and Alzheimer disease: Mounting evidence supports the fact that puerarin can attenuate cognitive impairment in AD mouse models through the suppression of apoptosis via activation of the phosphatidylinositol 3-kinase (PI3K)/Aktsignaling pathway [36-38], down-regulation of the Bax/Bcl-2 ratio, inhibition of c-Jun N-terminal Kinase (JNK), p38, and caspase-3 [39,40], and activation of estrogen receptor β [41].