MAPT and Alzheimer disease: Moreover, it was also reported that both Puerariae radix aqueous extract and puerarin alleviated cognitive impairment in an Aβ25-35-induced AD model by decreasing the levels of Aβ deposition and hyperphosphorylated tau protein, as well as by preventing neuroinflammation and the loss of noradrenergic and serotonergic neurons [21].