3xTg-AD running mice had elevated levels of synaptic proteins compared with 3xTg-AD sedentary controls (two-way ANOVA, F[1,20] = 46.85, 13.38, and 28.13 for PSD-95, GluR1, and synaptophysin, respectively; Tukey’s post hoc test, ** P < 0.01). Here, DLG4 is linked to Alzheimer disease.