As expected, a decreased expression of synaptic proteins was apparent in 3xTg-AD sedentary mice compared with Ntg sedentary mice ( F[1,20] = 76.31, 51.07, and 64.84 for PSD-95, GluR1, and synaptophysin, respectively; all P < 0.0001. This evidence concerns the gene DLG4 and Alzheimer disease.