Soto and co-workers knocked out insulin receptors and IGF-1 receptors in the hippocampus or central amygdala of mice, which in turn led to defective insulin signaling, as evidenced by decreased levels of GluA1 subunits of the glutamate AMPA receptor on the one hand and increased levels of anxiety-like behavior, cognitive impairment, and metabolic disturbances (e.g., glucose intolerance) on the other. Here, INS is linked to Anxiety.