In another study, 47 patients were identified as severe DIC by following criteria: Hypofibrinogenemia in the absence of a known cause other than DIC in addition to an abnormality in at least two of the following tests: platelet count, activated partial thromboplastin time (APTT), fibrin/fibrinogen degradation products (FDP) and prothrombin time (PT), and also having one or more clinical conditions predisposing the patient to DIC. This evidence concerns the gene F2 and Hypofibrinogenemia.