APOB and type 2 diabetes mellitus: Wägner et al. showed that the improvement in glycaemic control from HbA1c of 10.54 ± 2.05% to HbA1c of 7.01 ± 0.63% (p <0.0005) after a follow-up period of 3.5 months resulted in a significant reduction in LDL-C - from 3.62 ± 1.15 to 3.34 ± 1.02 mmol/L (p <0.05), and apo B from 1.17 ± 0.29 to 1.07 ± 0.25 g/L (p <0.01), with increase in LDL particle size from 25.10 ± 0.31 to 25.61 ±0.53 nm (p <0.005) in T2DM patients who had LDL phenotype B at baseline [36].