Lower baseline CD4 count (adjusted hazard ratio [aHR], 2.27 for <50 vs 100–150 cells/μL; 95% CI, 1.57–3.27), lower body mass index (aHR, 2.13 for BMI <17 vs ≥25 kg/m2; 95% CI, 1.31–3.45), presence of tuberculosis-related symptoms (aHR, 1.87 for 3–4 symptoms vs none; 95% CI, 1.20–2.93), detectable urine lipoarabinomannan (aHR, 1.97 for 1+ positivity vs negative; 95% CI, 1.37–2.83), and anemia (aHR, 4.42 for severe anemia [hemoglobin <8 g/dL] vs none; 95% CI, CI 2.38–8.21) were strong independent risk factors for hospitalization/death. This evidence concerns the gene CD4 and tuberculosis.